Compare Tylenol Arthritis Pain vs Tylenol Extra Strength head-to-head with other drugs for uses, ratings, cost, side effects and interactions. Tylenol 8-Hour Aches and Pains Extended-Release is basically the same as the formulation for arthritis pain. This type of Tylenol contains 650 mg acetaminophen per caplet, has the same bi-layer design, and is formulated to relieve minor muscle aches and body pain fast and to last all day. An Extra Strength Tylenol tablet packs 500mg of acetaminophen – a figure that jumps to 650mg per dose when you switch to a tablet from the Arthritis line-up. Also, how each product releases this shared component also differs significantly. Tylenol and Tylenol Arthritis contain the same active ingredient, acetaminophen. Their formulations and intended uses differ. Understanding these differences is key for safe and effective pain relief. The choice between Tylenol and Tylenol Arthritis depends on your specific pain management needs. If you have arthritis pain and reach for a Tylenol for relief, you may be doing yourself a disservice. According to a recent study, Tylenol is only a little bit better than a placebo for treating arthritis pain in the hip or knee. The biggest distinction is that Tylenol Arthritis is an extended-release tablet designed to spread its effect over eight hours, while standard Tylenol formulations release all their acetaminophen at once and wear off in four to six hours. Regular Tylenol tablets contain 325 mg of acetaminophen, while Extra-Strength caplets have 500 mg, and Tylenol Arthritis features 650 mg per tablet, making it suitable for intense pain relief. Discover the key differences between Tylenol and Tylenol Arthritis and how they affect arthritis management. Read more to choose the right option for you. Tylenol Arthritis contains a higher dose of acetaminophen and features an extended-release formula, providing longer-lasting relief than regular Tylenol. In our latest question and answer, the pharmacist discusses the difference between Tylenol Arthritis and Tylenol Extra Strength.